How to Take SUTENT

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Before taking SUTENT

Tell your healthcare provider if you:

  • Have any heart problems
  • Have high blood pressure
  • Have thyroid problems
  • Plan to have surgery
  • Have kidney function problems (other than cancer)
  • Have liver problems
  • Have any bleeding problem
  • Have seizures
  • Have any other medical conditions
  • Are pregnant, could be pregnant, or plan to become pregnant. SUTENT may harm an unborn baby. You should not become pregnant while taking SUTENT. Tell your healthcare provider right away if you become pregnant while taking SUTENT
  • Are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will take SUTENT or breastfeed. You should not do both

Tell your healthcare provider about all the medicines you take, including prescription medicines and nonprescription medicines, vitamins, and herbal supplements. Using SUTENT with certain other medicines can cause serious side effects. You may have an increased risk of severe jaw bone problems (osteonecrosis) if you take SUTENT and a bisphosphonate medicine (Actonel, Aredia, Boniva, Didronel, Fosamax, Reclast, Skelid, or Zometa). Talk with your healthcare provider before starting any new medicines.

Tell all of your healthcare providers and dentists that you are taking SUTENT. They should talk to the healthcare provider who prescribed SUTENT for you, before you have any surgery, or medical or dental procedure.

Important things to remember

Here are a few things you should know about taking SUTENT:

  • Do not open the SUTENT capsules
  • Take SUTENT 1 time each day with or without food
  • If you miss a dose, take it as soon as you remember. Do not take it if it is close to your next dose. Just take the next dose at your regular time. Do not take more than 1 dose of SUTENT at a time. Tell your healthcare provider about any missed dose
  • Your healthcare provider may do blood tests before each cycle of treatment
  • Call your healthcare provider right away if you take too much SUTENT
  • Tell your doctor or nurse about all the medicines, vitamins, or herbal products you use
  • Do not become pregnant while taking SUTENT. SUTENT may harm an unborn baby (cause birth defects). If you do become pregnant, tell your doctor right away. Stop taking SUTENT

What not to take with SUTENT

Using SUTENT with other medicines can cause serious side effects. Tell your doctor or nurse about all the medicines, vitamins, or herbal products you use.

  • Do not drink grapefruit juice or eat grapefruit because this can change the amount of SUTENT in your body
  • Do not take St. John's Wort while taking SUTENT

Easy ways to remember each dose

Since you only have to take SUTENT once a day, there are simple ways to remember each dose. Here are a few ideas you can try:

  • Make medicine a part of your daily routine—Take your medicine every day at the same time. For example, you may want to take it when you wake up in the morning, or just before you go to bed.
  • Use a weekly or monthly pill caddy—It can help you keep count of your capsules in advance, and to remember to take each day’s dose.
  • Plan ahead—If possible, get your refills before your next treatment cycle starts.
  • Place your pill bottle in plain sight—Keep your medicine where you will see it, such as on your nightstand. Just make sure it is out of the reach of children and pets.
  • Always carry an extra dose with you—No matter where you are, you will always have your medicine on hand.
  • Use a calendar—Record your dosage times on a calendar or planner. You can then check off each dose as you take it.
  • Use a diary or journal—Track your medicine and when it is time to take it. You can also use it to track symptoms and side effects for doctor visits.
  • Ask for a reminder—A caregiver, friend, or family member can help remind you to take each dose of your medicine. Just ask.

Have questions about your dose? On the next page, you will learn about the recommended dosage of SUTENT.

IMPORTANT SAFETY INFORMATION

SUTENT can cause serious liver problems, including death.

Tell your healthcare provider right away if you develop any of the following signs and symptoms of liver problems during treatment with SUTENT:

  • Itching
  • Yellow eyes or skin
  • Dark urine
  • Pain or discomfort in the right upper stomach area

Your healthcare provider should do blood tests to check your liver function before you start taking SUTENT and during treatment.

Pregnancy and breastfeeding:

  • SUTENT may harm an unborn baby. You should not become pregnant while taking SUTENT. Tell your healthcare provider right away if you become pregnant while taking SUTENT
  • Do not breastfeed while taking SUTENT

Tell your healthcare provider about all the medicines you take, including prescription medicines and nonprescription medicines, vitamins, and herbal supplements. Using SUTENT with certain other medicines can cause serious side effects. You may have an increased risk of severe jaw bone problems (osteonecrosis) if you take SUTENT and a bisphosphonate medicine (Actonel, Aredia, Boniva, Didronel, Fosamax, Reclast, Skelid, or Zometa). Talk with your healthcare provider before starting any new medicines.

Tell all of your healthcare providers and dentists that you are taking SUTENT. They should talk to the healthcare provider who prescribed SUTENT for you, before you have any surgery, or medical or dental procedure.

SUTENT may cause serious side effects, including:

  • Serious liver problems, including death
  • Heart problems—Heart problems may include heart failure and heart muscle problems (cardiomyopathy) that can lead to death. Tell your healthcare provider if you feel very tired, are short of breath, or have swollen feet and ankles
  • Abnormal heart rhythm changes—Your healthcare provider may do electrocardiograms and blood tests to watch for these problems during your treatment with SUTENT. Tell your healthcare provider if you feel dizzy, faint, or have abnormal heartbeats
  • High blood pressure—Your healthcare provider may check your blood pressure during treatment with SUTENT. Your healthcare provider may prescribe medicine for you to treat high blood pressure, if needed
  • Bleeding sometimes leading to death—Tell your healthcare provider right away if you have any of these symptoms or a serious bleeding problem:
    • Painful, swollen stomach (abdomen)
    • Bloody urine
    • Vomiting blood
    • Headache or change in your mental status
    • Black, sticky stools
    Your healthcare provider can tell you other symptoms to watch for.
  • Jaw-bone problems (osteonecrosis)—Severe jaw bone problems may happen. Your healthcare provider should examine your mouth before you start SUTENT. Your healthcare provider may tell you to see your dentist before you start SUTENT
  • Tumor lysis syndrome (TLS)—TLS is caused by the fast breakdown of cancer cells and may lead to death. TLS may cause you to have nausea, shortness of breath, irregular heartbeat, clouding of urine and tiredness associated with abnormal laboratory test results (high potassium, uric acid and phosphorus levels and low calcium levels in the blood) that can lead to changes in kidney function and acute kidney failure. Your healthcare provider may do blood tests to check you for TLS
  • Protein in your urine—Your healthcare provider will check you for this problem. If there is too much protein in your urine, your healthcare provider may tell you to stop taking SUTENT
  • Serious skin and mouth reactions—SUTENT can cause serious skin reactions that can cause death. This can include rash, widespread blistering or peeling of the skin and blistering and peeling on the inside of your mouth. If you develop a rash or these skin symptoms, tell your healthcare provider immediately. Your healthcare provider may tell you to stop taking SUTENT
  • Hormone problems, including thyroid and adrenal gland problems—Your healthcare provider may do tests to check your thyroid and adrenal gland function during SUTENT treatment. Tell your doctor if you have any of the following signs and symptoms:
    • Tiredness that worsens and does not go away
    • Fast heart rate
    • Loss of appetite
    • Weight gain or weight loss
    • Heat intolerance
    • Feeling depressed
    • Feeling nervous or agitated, tremors
    • Irregular menstrual periods or no menstrual periods
    • Sweating
    • Headache
    • Nausea or vomiting
    • Hair loss
    • Diarrhea

Common side effects of SUTENT include:

  • The medicine in SUTENT is yellow, and it may make your skin look yellow. Your skin and hair may get lighter in color
  • Tiredness
  • Weakness
  • Fever
  • Gastrointestinal symptoms, including diarrhea, nausea, vomiting, mouth sores, upset stomach, abdominal pain, and constipation. Talk with your healthcare provider about ways to handle these problems
  • Rash or other skin changes, including drier, thicker, or cracking skin
  • Blisters or a rash on the palms of your hands and soles of your feet
  • Taste changes
  • Loss of appetite
  • Pain or swelling in your arms or legs
  • Cough
  • Shortness of breath
  • Bleeding, such as nosebleeds or bleeding from cuts

Call your healthcare provider if you have any swelling or bleeding during treatment with SUTENT.

INDICATIONS

SUTENT is used to treat advanced kidney cancer (advanced renal cell carcinoma or RCC).

*SUTENT is used to treat GIST (gastrointestinal stromal tumor). This is a rare cancer of the stomach, bowel, or esophagus. SUTENT is used when the medicine Gleevec® (imatinib mesylate) did not stop the cancer from growing, or when you cannot take Gleevec.

SUTENT is used to treat a type of pancreatic cancer known as pancreatic neuroendocrine tumors (pancreatic NET), that has progressed and cannot be treated with surgery.

Gleevec is a registered trademark of Novartis AG.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or
call 1-800-FDA-1088.

Please see patient Medication Guide and full Prescribing Information, including Boxed Warning regarding serious liver problems.

 

LEARN HOW TO TAKE SUTENT
WITH NURSE TRISH CREEL

video

Scroll for Important Safety Information and Indication 

IMPORTANT SAFETY INFORMATION

SUTENT can cause serious liver problems, including death.

Tell your healthcare provider right away if you develop any of the following signs and symptoms of liver problems during treatment with SUTENT:

  • Itching
  • Yellow eyes or skin
  • Dark urine
  • Pain or discomfort in the right upper stomach area

Your healthcare provider should do blood tests to check your liver function before you start taking SUTENT and during treatment.

Pregnancy and breastfeeding:

  • SUTENT may harm an unborn baby. You should not become pregnant while taking SUTENT. Tell your healthcare provider right away if you become pregnant while taking SUTENT
  • Do not breastfeed while taking SUTENT

Tell your healthcare provider about all the medicines you take, including prescription medicines and nonprescription medicines, vitamins, and herbal supplements. Using SUTENT with certain other medicines can cause serious side effects. You may have an increased risk of severe jaw bone problems (osteonecrosis) if you take SUTENT and a bisphosphonate medicine (Actonel, Aredia, Boniva, Didronel, Fosamax, Reclast, Skelid, or Zometa). Talk with your healthcare provider before starting any new medicines.

Tell all of your healthcare providers and dentists that you are taking SUTENT. They should talk to the healthcare provider who prescribed SUTENT for you, before you have any surgery, or medical or dental procedure.

SUTENT may cause serious side effects, including:

  • Serious liver problems, including death
  • Heart problems—Heart problems may include heart failure and heart muscle problems (cardiomyopathy) that can lead to death. Tell your healthcare provider if you feel very tired, are short of breath, or have swollen feet and ankles
  • Abnormal heart rhythm changes—Your healthcare provider may do electrocardiograms and blood tests to watch for these problems during your treatment with SUTENT. Tell your healthcare provider if you feel dizzy, faint, or have abnormal heartbeats
  • High blood pressure—Your healthcare provider may check your blood pressure during treatment with SUTENT. Your healthcare provider may prescribe medicine for you to treat high blood pressure, if needed
  • Bleeding sometimes leading to death—Tell your healthcare provider right away if you have any of these symptoms or a serious bleeding problem:
    • Painful, swollen stomach (abdomen)
    • Bloody urine
    • Vomiting blood
    • Headache or change in your mental status
    • Black, sticky stools
    Your healthcare provider can tell you other symptoms to watch for.
  • Jaw-bone problems (osteonecrosis)—Severe jaw bone problems may happen. Your healthcare provider should examine your mouth before you start SUTENT. Your healthcare provider may tell you to see your dentist before you start SUTENT
  • Tumor lysis syndrome (TLS)—TLS is caused by the fast breakdown of cancer cells and may lead to death. TLS may cause you to have nausea, shortness of breath, irregular heartbeat, clouding of urine and tiredness associated with abnormal laboratory test results (high potassium, uric acid and phosphorus levels and low calcium levels in the blood) that can lead to changes in kidney function and acute kidney failure. Your healthcare provider may do blood tests to check you for TLS
  • Protein in your urine—Your healthcare provider will check you for this problem. If there is too much protein in your urine, your healthcare provider may tell you to stop taking SUTENT
  • Serious skin and mouth reactions—SUTENT can cause serious skin reactions that can cause death. This can include rash, widespread blistering or peeling of the skin and blistering and peeling on the inside of your mouth. If you develop a rash or these skin symptoms, tell your healthcare provider immediately. Your healthcare provider may tell you to stop taking SUTENT
  • Hormone problems, including thyroid and adrenal gland problems—Your healthcare provider may do tests to check your thyroid and adrenal gland function during SUTENT treatment. Tell your doctor if you have any of the following signs and symptoms:
    • Tiredness that worsens and does not go away
    • Fast heart rate
    • Loss of appetite
    • Weight gain or weight loss
    • Heat intolerance
    • Feeling depressed
    • Feeling nervous or agitated, tremors
    • Irregular menstrual periods or no menstrual periods
    • Sweating
    • Headache
    • Nausea or vomiting
    • Hair loss
    • Diarrhea

Common side effects of SUTENT include:

  • The medicine in SUTENT is yellow, and it may make your skin look yellow. Your skin and hair may get lighter in color
  • Tiredness
  • Weakness
  • Fever
  • Gastrointestinal symptoms, including diarrhea, nausea, vomiting, mouth sores, upset stomach, abdominal pain, and constipation. Talk with your healthcare provider about ways to handle these problems
  • Rash or other skin changes, including drier, thicker, or cracking skin
  • Blisters or a rash on the palms of your hands and soles of your feet
  • Taste changes
  • Loss of appetite
  • Pain or swelling in your arms or legs
  • Cough
  • Shortness of breath
  • Bleeding, such as nosebleeds or bleeding from cuts

Call your healthcare provider if you have any swelling or bleeding during treatment with SUTENT.

INDICATIONS

SUTENT is used to treat advanced kidney cancer (advanced renal cell carcinoma or RCC).

*SUTENT is used to treat GIST (gastrointestinal stromal tumor). This is a rare cancer of the stomach, bowel, or esophagus. SUTENT is used when the medicine Gleevec® (imatinib mesylate) did not stop the cancer from growing, or when you cannot take Gleevec.

SUTENT is used to treat a type of pancreatic cancer known as pancreatic neuroendocrine tumors (pancreatic NET), that has progressed and cannot be treated with surgery.

Gleevec is a registered trademark of Novartis AG.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or
call 1-800-FDA-1088.

Please see patient Medication Guide and full Prescribing Information, including Boxed Warning regarding serious liver problems.